Letters to NatureNature 434, 505-509 (24 March 2005) | doi:10.1038/nature03380; Received 8 December 2004; Accepted 21 January 2005 There is a Brief Communications Arising (1 September 2005) associated with this document. Собираю эту точку зрения на странице pcp103 There is a Brief Communications Arising (1 September 2005) associated with this document.Собираю эту точку зрения на странице pcp104 Ответ авторов на эти 2 замечания Собираю на странице pcp105 There is a Brief Communications Arising (28 September 2006) associated with this document.Собираю эту точку зрения на странице pcp106 There is a Brief Communications Arising (28 September 2006) associated with this document. Ответ авторов на это замечание Собираю на странице pcp107 Genome-wide non-mendelian inheritance of extra-genomic information in ArabidopsisSusan J. Lolle1,2, Jennifer L. Victor1, Jessica M. Young1 & Robert E. Pruitt2
Correspondence to: Robert E. Pruitt2 Correspondence and requests for materials should be addressed to R.E.P. (Email: pruittr@purdue.edu). A fundamental tenet of classical mendelian genetics is that allelic information is stably inherited from one generation to the next, resulting in predictable segregation patterns of differing alleles1. Although several exceptions to this principle are known, all represent specialized cases that are mechanistically restricted to either a limited set of specific genes (for example mating type conversion in yeast2) or specific types of alleles (for example alleles containing transposons3 or repeated sequences4). Here we show that Arabidopsis plants homozygous for recessive mutant alleles of the organ fusion gene HOTHEAD 5 (HTH) can inherit allele-specific DNA sequence information that was not present in the chromosomal genome of their parents but was present in previous generations. This previously undescribed process is shown to occur at all DNA sequence polymorphisms examined and therefore seems to be a general mechanism for extra-genomic inheritance of DNA sequence information. We postulate that these genetic restoration events are the result of a template-directed process that makes use of an ancestral RNA-sequence cache. |
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