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\bibitem{pcp102} Detlef Weigel & Gerd Jurgens. Genetics:  Hotheaded healer // Nature 434, 443 (24 March 2005). N&V of \cite{pcp101}  Горячий целитель - здесь буквально, исцеление геном HOTHEAD

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Genetics:  Hotheaded healer p443

A previously unknown way of reversing genome-wide sequence changes in DNA has been revealed by an analysis of plants carrying mutations in a gene called HOTHEAD. The mechanism remains a mystery.

Detlef Weigel and Gerd Jürgens

doi:10.1038/434443a

Full Text | PDF (504K)

See also: Editor's summary


Editor's Summary

24 March 2005

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The principle of inheritance first observed by Mendel is clear enough. Genetic information passes from parent to offspring in the DNA carried in the chromosomes found in every cell of the organism — and to a lesser extent in auxiliary genomes in organelles such as mitochondria and chloroplasts. But analysis of revertant hothead gene mutants inArabidopsis thaliana suggests that these plants can inherit information not found in parental chromosomes, but identical to that of a grandparent or more distant forebear. This may involve template-directed restoration of ancestral DNA passed on in an RNA cache, like a web browser cache that delivers an old page. It will be intriguing to discover if this type of inheritance is widespread. On the cover, a hothead mutant inflorescence (SEM by M. A. Webb).

NEWS AND VIEWS:Genetics:  Hotheaded healer

A previously unknown way of reversing genome-wide sequence changes in DNA has been revealed by an analysis of plants carrying mutations in a gene called HOTHEAD. The mechanism remains a mystery.

Detlef Weigel and Gerd Jürgens

doi:10.1038/434443a

Full Text | PDF (504K)

LETTER:Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis

Susan J. Lolle, Jennifer L. Victor, Jessica M. Young and Robert E. Pruitt

doi:10.1038/nature03380

First paragraph | Full Text | PDF (296K)




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