Desmosome

http://en.wikipedia.org/wiki/Desmosome  This page was last modified on 11 September 2010 at 22:20. 18/9/10

Desmosome

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desmosomes
Cell adhesion in desmosomes

desmosome (Greek: desmos, band, soma, body), also known as macula adherens (plural: maculae adherentes) (Latin for adhering spot), is a cell structure specialized for cell-to-cell adhesion. A type of junctional complex, they are localized spot-like adhesions randomly arranged on the lateral sides of plasma membranes.

Desmosomes help to resist shearing forces and are found insimple and stratified squamous epithelium. The intercellular space is very wide (about 30 nm). Desmosomes are also found in muscle tissue where they bind muscles cells to one another.

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[edit]Structure

Desmosomes are molecular complexes of cell adhesion proteins and linking proteins that attach the cell surface adhesion proteins to intracellularkeratin cytoskeletal filaments.

The cell adhesion proteins of the desmosome, desmoglein and desmocollin, are members of the cadherin family of cell adhesion molecules. They aretransmembrane proteins that bridge the space between adjacent epithelial cellsby way of homophilic binding of their extracellular domains to other desmosomal cadherins on the adjacent cell. Both have five extracellular domains, and have calcium-binding motifs.

The extracellular domain of the desmosome is called the Extracellular Core Domain (ECD) or the Desmoglea, and is bisected by an electron-dense midline where the desmoglein and desmocollin proteins bind to each other. These proteins can bind in a W, S, or λ manner.

On the cytoplasmic side of the plasma membrane, there are two dense structures called the Outer Dense Plaque (ODP) and the Inner Dense Plaque (IDP). These are spanned by the Desmoplakin protein.[1] The Outer Dense Plaque is where the cytoplasmic domains of the cadherins attach to desmoplakin via plakoglobin and plakophillin. The Inner Dense Plaque is where desmoplakin attaches to the intermediate filaments of the cell.

[edit]Blistering diseases

If the connecting adjacent epithelial cells of the skin are not functioning correctly, layers of the skin can pull apart and allow abnormal movements of fluid within the skin, resulting in blisters and other tissue damage. Blistering diseases such asPemphigus vulgaris or Pemphigus foliaceus can be due to genetic defects in desmosomal proteins. The symptoms of the disease are thought to be caused by an abnormality in the desmosome-keratin filament complex leading to a breakdown in cell adhesion

[edit]See also

[edit]References

  1. ^ Bornslaeger EA, Corcoran CM, Stappenbeck TS, Green KJ (Aug 1996). "Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly"Journal of Cell Biology 134 (4): 985–1001.doi:10.1083/jcb.134.4.985ISSN 0021-9525PMID 8769422. edit

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Histologyepithelial tissue
Types
Features
Lateral/cell-cell
Apical



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